The science behind Jetmojo

What is jet lag?

The travelers nemesis. Jet lag, also called flight fatigue, is a temporary psychophysical disorder. Despite the common belief, it is much more than plain tiredness!

Jet lag causes an unpleasant and limiting blend of fatigue, disorientation, nausea and many other symptoms including the most unpopular one - insomnia.

Why does jet lag happen?

When more than 3 time zones are crossed too fast, especially if you fly in an easterly direction, this dramatic shift disrupts your body in various ways.

The part of your body that gets most confused is your inner body clock: your circadian rhythm. The circadian rhythm is the system that controls your sleep / wake patterns and is responsible for making you feel tired at the same point each night. But what exactly makes that body clock work?

Of course, it’s a hormone. Melatonin is a hormone released by the pineal gland in your brain, and it reacts to the surrounding amount of light. This is why it’s easiest to fall asleep when it’s dark. When you cross multiple time zones, your circadian rhythm isn’t yet synchronized with your destination time zone and your body will produce melatonin at the wrong times. This is why various (mainly, sleeping) disorders appear.

Your body needs time to fully adjust to the new circumstances at your destination. So, besides insomnia, you might also feel disoriented, fatigued, and your appetite may be disrupted as a part of jet lag.

How many people struggle with jet lag?

As shown in two sources: the major US study by Upjohn, in cooperation with United Airlines and British Airways, and the 1994 survey conducted with flight attendants on international routes, too many people regularly suffer from jet lag:

• 96% of long-distance travelers experience jet lag

• 90% of frequent flyers reported overwhelming tiredness upon arrival

• 73% of flight crew commonly suffer from dehydration due to jet lag

• 94% of global travlers reported the lack of concentration after long flights

• 93% of long-distance passengers regularly fight with insomnia

What is Jetmojo?

Jetmojo is a perfect partnership of carefully formulated supplements that make severe jet lag a thing of a past.

There are two products for you to enjoy, both made out of easily-recognisable ingredients such as vitamins, minerals and amino acids:

  1. Wide Awake - for energized, daytime alertness
  2. Deep Sleep - for a refreshing, revitalizing rest

A team of experts, particularly experienced in supplement production, formulated our products. Our manufacturer is located in the USA and has obtained all cGMP* (Current Good Manufacturing Practice) certifications.

Jetmojo is made for travelers, by travelers. The founders of Jetmojo regularly take these products whenever they’re traveling long-distance. Read on and discover why you should also make Jetmojo an essential part of your luggage.

Our AM solution - The science behind Wide Awake

The main ingredient of our Wide Awake formula is the well-known caffeine. This natural stimulant provides focus, alertness, and energy, but also helps your body clock to align with your new time zone.

It has been scientifically proven through systematic reviews, that caffeine can make you more alert and productive while suffering through jet lag - as stated in the Pharmacy and Therapeutics Journal:

“In a systematic review of 13 randomized trials of persons with jet lag or shift-work disorder, caffeine improved concept formation, reasoning, memory, orientation, attention, and perception when compared with placebo.” 1

Knowing this, we felt the urge to create a perfect mix of high-quality ingredients that will help you stay awake and perform at your best in a new destination.

Ingredients How Much We've Added Why?


Natural stimulant


The purest form of caffeine available we choose for this supplement, maximizes your focus and alertness.

Caffeine acts on the central nervous system, metabolism and neuromuscular function, which makes it a superb traveling ally.

“The findings of research studies involving caffeine supplementation and physical performance indicate a combined effect on both the central and peripheral systems.” 2


Natural amino acid, commonly found in green tea


Sometimes, caffeine can be too stimulatory. This is why we combined it with L-Theanine, a calming amino acid.

Plus, besides its relaxing effect, L-Theanine also improves your memory and concentration.

“The combination of L-Theanine and caffeine improves cognitive performance and increases subjective alertness.” 3


Form of black pepper


We left nothing to chance. Our faithful sidekick, BioPerine®, helps you efficiently absorb all the powerful ingredients.

Learn more about BioPerine® here.

Our PM solution - The science behind Deep Sleep

The essential ingredient of our Deep Sleep formula is melatonin. Numerous scientific studies show that this naturally produced hormone (secreted by the pineal gland in your brain) controls your circadian rhythm. In this way, melatonin induces a deep, revitalizing sleep - just the thing you need after a long flight.

As shown in this research published in Medwave:

“Melatonin probably reduces symptoms related to jet lag syndrome in travelers crossing more than five time zones.” 4

After long-distance travel, the body is secreting melatonin at the wrong time (ie. at the time you would normally sleep in your previous timezone). When you choose to supplement melatonin for a few days, it actually helps your body to adjust and overcome the main symptom of jet lag - sleep disorders.

But, melatonin itself is not enough, so we've created the perfect blend of 6 powerful ingredients.

Ingredients How Much We've Added Why?


Natural hormone that controls your sleep / wake cycle


Melatonin is naturally secreted by the pineal gland in the brain as a sign for your body that it is time for sleep.

The primary use of melatonin in our product is to allow your body to adjust to a sleep pattern that fits your new timezone.

“Melatonin at doses of 2 mg to 5 mg taken before bedtime over 2 to 4 days is effective in reducing jet-lag symptoms.” 5


Natural amino acid, commonly found in green tea


L-Theanine has a calming but non-sedative effect and can be used to calm the mind before bedtime.

L-Theanine is able to cross the blood brain barrier and as a result it helps the mind to quiet down neural processes before sleep.

“L-Theanine offers relaxation without drowsiness.” 6



This vitamin improves the quality of your sleep. Zinc helps in metabolising melatonin which is essential for getting regular and uninterrupted sleep at night.



Magnesium regulates cortisol and has been shown to reduce restless leg syndrome.

Vitamin B6


Vitamin B6 helps with the production of serotonin (a neurotransmitter responsible for the regulation of sleep patterns and mood).


Form of black pepper


It increases the absorption rates of supplements as it inhibits enzymes that would attack other molecules.

“BioPerine® received Generally Recognized As Safe (GRAS) status after a comprehensive review of safety and toxicology data.” 7


1 Choy, M., & Salbu, R. L. (2011). Jet Lag: Current and Potential Therapies. Pharmacy and Therapeutics, 36(4), 221–231.

2 Goldstein ER, Ziegenfuss T, Kalman D, et al. International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition. 2010;7:5.

3 Giesbrecht, T., Rycroft, JA., Rowson, MJ. and De Bruin, EA. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283-290.

4 Tortorolo, F., Farren, F. and Rada, G. (2015). Is melatonin useful for jet lag?. Medwave, 15(Suppl 3):e6343.

5 Zee, P. C., Attarian, H., & Videnovic, A. (2013). Circadian Rhythm Abnormalities. Continuum : Lifelong Learning in Neurology, 19(1 Sleep Disorders), 132–147.

6 Rao, T. P., Ozeki, M., and Juneja, L. R. (2015) In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition 34, 436-447.


* cGMP refers to the regulations enforced by the US FDA - Food and Drug Administration. 21 CFR 111: cGMP in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements. These regulations assure proper design, monitoring, and control of manufacturing processes, packaging processes and facilities. Dietary supplements meet established specifications for identity, purity, strength, composition, and do not exceed their limits for contaminants.

Piérard, C., Beaumont, M., Enslen, M. et al. (2001). Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin. Eur J Appl Physiol, 85, 144-150.

Herxheimer A, Petrie KJ. (2002). Melatonin for the prevention and treatment of jet lag. Cochrane Database of Systematic Reviews, 2.

Noyek, S., Yaremchuk, K. and Rotenberg, B. (2016), Does melatonin have a meaningful role as a sleep aid for jet lag recovery?. The Laryngoscope, 126, 1719–1720.

Morgenthaler, T. I., Lee-Chiong, T., Alessi, C., Friedman, L., Aurora, R. N., Boehlecke, B., … Standards of Practice Committee of the AASM, R. (2007). Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders: An American Academy of Sleep Medicine Report. Sleep, 30(11), 1445–1459.

Türközü, D., Şanlier, N. (2017). L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit Rev Food Sci Nutr, 57(8), 1681-1687.

Owen, GN., Parnell, H., De Bruin, EA. and Rycroft, JA. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193-198.

Bryan, J. (2008). Psychological effects of dietary components of tea: caffeine and L-theanine. Nutrition Reviews, 66 (2), 82-90.

Kelly, SP., Gomez-Ramirez, M., Montesi, JL. and Foxe, JJ. (2008). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. The Journal of Nutrition., 138(8), 1572S-1577S.